Hex Non-Inverting Buffers. Datasheet ( KB) without level translation. The ‘ HC and ‘HC are enhanced versions of equivalent CMOS types. Symbol. Parameter. Value. Unit. VCC. Supply Voltage. to +7. V. VI. DC Input Voltage. to V. VO. DC Output Voltage. to VCC + V. IIK. DC Input. M54HCF1R datasheet, M54HCF1R pdf, M54HCF1R data sheet, datasheet, data sheet, pdf, SGS Thomson Microelectronics, HC HEX.

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Monosphosphoryl Lipid A (MPL-A) from E.coli, R515 (Re)

Acute phase proteins Adhesion molecules Antimicrobial peptides Cell damage and toxicity Coagulation molecules Complement and collectins.

Original supplier of innate immunity products since Related Products Lipid A from E. Description Specifications Application Downloads Description. Details Humans as well as other vertebrates are often exposed to lipopolysaccharide LPSfor instance via enterobacteria. TLRs are conserved pattern recognition receptors which recognize and respond to molecules derived from bacterial, viral and fungal pathogens, datasheef as LPS from the outer membrane of Gram negative bacteria.

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All immunological activity of LPS is exclusively dependent upon the presence of TLR4 as determined by the usage of the corresponding control cells, where TLR4 is missing. Recognition of LPS triggers a cascade of adverse systemic responses and organ failure septic shock. The molecule consist of three structural regions: The latter is responsible for the endotoxic activity of the entire molecule.

R-form LPS synthesized by the so-called rough R mutants of gram-negative bacteria lacks the O-specific chain. Furthermore, the core-oligosaccharide may be present in different degrees of completion, depending on the class Ra to Re to which the mutant belongs.

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LPS from wild type bacteria are always a highly heterogeneous mixtures of S-form LPS molecules containing 1 to over 50 repeating oligosaccharide units and contain a varying proportion of R-form molecules.

S- and R-form LPS show marked differences in the kinetics of their blood clearance and cellular uptake as well as in the ability to induce oxidative burst in human granulocytes and to activate the host complement system.

This mechanism is believed to be true for LPS signaling in general. LPS is an amphipathic molecule whose hydrophobicity decreases when the length of the sugar part of LPS increases. MPL-A represents an important adjuvant in vaccines. Under recommended storage conditions, product is stable for at least one year.


The exact expiry date is indicated on the label. Precautions For research use only. Not for use in or on humans or animals or for diagnostics. Use of this product for human or animal testing is extremely hazardous and may result in disease, severe injury, or death.

Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. Material Safety Data Sheet: This material should be considered hazardous until information to the contrary becomes available. Do not ingest, swallow, inhale or get in the blood stream.

Do not pre-dilute in buffer, e. Prepare diluted MPLA working solutions just prior to use, keep sterile. Ready-made solution is cell culture-grade. Optimal concentration is dependent upon cell type, species, desired activation and analysis: For research use only.