Key words: Intravenous anesthesia, remifentanyl, propofol, infusion pump, .. Aguilera L. Conceptos básicos de farmacocinética farmacodinámia en TIVA. Propofol nanoemulsion is a new formulation consisting of nanoemulsified systems, characterized by the absence of lipid vehicle. Changes in drug vehicle may. Anestesia-Reanimación – A – Propofol – EM|consulte.

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Kay B, Stephenson DK. Relationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points. What is the rate of infusion? Manual versus target-controlled infusions of propofol. However, the TCI system used higher levels of propofol Tracheal intubating conditions using propofol and remifentanil target-controlled infusion: Relationship between the pharmacokinetics and pharmacodynamics of procainamide.

Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients: Infusion systems add several advantages to TIVA and make it essential for both ambulatory and highly complex procedures. The fast peripheral compartment V2 is the central compartment from which the drug perfuses rapidly. As such, between the extremes of 20 and 80 years the different ages can be placed. British Journal of Anaesthesia ; Via this technique one achieves the intubation dose and maintains the desired concentration.

Manual Infusion Regimens Traditionally, before the TCI system came about, intravenous anesthetics were administered using manual regimens. The influence of age on propofol pharmacodynamics. In the inferior extreme, are the year-old patients, and in the superior, the year-olds. Morphine has a considerably smaller ke0 and a longer delay for the onset of action 19, Afterwards the infusion rate changes every 10 minutes, which corresponds to points C, D, E and F.

Halford 3 in described the use of Pentothal combined with morphine as an anesthetic technique used during World Was II, but with unfortunate outcomes because its pharmacokinetics was unknown. It can also be accomplished with a target effect-site concentration of propofol of 5. The goal is to maintain a constant, accurate and predictable concentration within a therapeutic window that ensures the desired effect.


The most relevant articles were selected for this review and it was supplemented with anesthesia textbooks in the guearea fsrmacocinetica pharmacokinetics and total intravenous anesthesia. How to cite this article. The simultaneous administration of anesthetic agents gives rise to different interactions that can be additive, empowering or inhibitory.

They received both propofol formulations administered as a bolus dose of 8mg kg -1 followed by 60 minutes farmacoinetica infusion at 0. Taking the rate of infusion that corresponds to this point in the axis of the Y, one observes that it is approximately 3.

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For this, one pinpoints the red line located on the nomogram. For instance, the effective dose 50 ED 50 for post-operative pain inhibition is 5. The availability of medications such as remifentanyl and propofol has made anesthesiologists feel the need to understand the basics of total intravenous anesthesia TIVA.

Interaction of propofol and sevoflurane on loss of consciousness and movement to skin incision during farmacoxinetica anesthesia. The heavier the patient, the higher the V1.

The phar mace utical and phar mac oki netic phase The development of total intravenous anesthesia is closely linked to the development of infusion systems. The pharmacokinetic administration of a drug requires the support of infusion devices programmed according to pre-determined and studied pharmacokinetic models whose accuracy has been endorsed.

In this case the body is mathematically represented into several compartments 14not as real containers in the body but representing how the drug travels through the bloodstream from one compartment to the next.

The development of tools such as the evoked potentials in and the BIS Bispectral Index in paved the way to the idea of administering drugs based not just on their pharmacokinetic principles, but also on their pharmacodynamics 7. Target controlled infusion in practice.

With the advent of sodium thiopental inintravenous anesthesia became popular.

Practical Application of Nomograms of Remifentanil and Propofol

Fentanyl and sufentanyl have an intermediate ke0 resulting in a slow onset of action 4 to 6 minutes. If we were to infer from this model the drug concentrations needed for farmacocindtica target effect, and identified the different concentrations that cause the same effect, what would then be the ideal concentration of each drug for delivering porpofol intraoperative anesthesia and a rapid recovery of the patient?


Rev Esp Anestesiol Reanim. A comparison with Althesin. In the best of cases, there is one infusion pump per room. The following step consists of propfol which is the desired CP according to the procedure.

La farmwcocinetica intravenosa II. The development of total intravenous anesthesia is closely linked to the development of infusion systems. As the constant of the Ke0 of the propofol is not so fast, the state of stabilization will not be so fast. In the fzrmacocinetica article the utilization of the nomograms are presented didactically via examples which permit the reader to assess her or his grade of comprehension and dispel doubts about the application of the pharmacokinetic concepts for remifentanil and propofol.

Propofol anesthesia and rational opioid selection: Pharmacokinetics, pharmacodynamics, and rational opioid selection. The time the drug needs to reach an equilibrium rate between V1 and the effectsite is represented by the velocity constant k1e and the equilibrium constant between Ve and V1 is ke1.

A general method for calculating the dosage scheme in linear pharmacokinetics. The infusion that corresponds to the axis of the Y is approximately 5. Propofol nomogram Therefore, as it is necessary to know what remifentanil CP is required in accordance with the moment of surgery and the type of intervention, it is also imperative to know which propofol CP is adequate: The following are some examples regarding the way to utilize nomograms during anesthesia.

There are three types of pharmacokinetic models 1: Pharmacodynamic Interactions The simultaneous administration of anesthetic agents gives rise to farmacocimetica interactions that can be additive, empowering or inhibitory.

Pharmacokinetics and pharmacodynamics of remifentanyl.