Intrarenal control of renal function is by tubuloglomerular feedback and by glomerulotubular balance. In tubu- loglomerular feedback, Na/Cl delivery to the. Tubuloglomerular feedback is an adaptive mechanism that links the rate of glomerular . Intrinsic—Tubuloglomerular Feedback and Glomerulotubular Balance. Glomerulotubular Balance refers to the phenomenon whereby a constant layer of protection if mechanisms of tubuloglomerular feedback, that normalize rates.

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The American Journal of Physiology. Central venous Right atrial ventricular pulmonary artery wedge Left atrial ventricular Aortic. The Mechanisms of Body Function. Reduced Tubiloglomerular uptake via the NKCC2 at the macula densa leads to increased renin release, which leads to restoration of plasma volume, and to dilation of the afferent arterioles, which leads to increased renal plasma flow and increased GFR. The macula densa’s detection of elevated sodium chloride concentration in the tubular lumen, which leads to a decrease in GFR, is based on the concept of purinergic signaling.

This consequently alters the balance of transcapillary fluid exchange in the peritubular capillary bed. Physiology of the kidneys and acid-base physiology.

When that blood enters the peritubular capillaries, the higher oncotic pressure increases reabsorption of filtrate from the renal tubules. In the physiology of the kidneytubuloglomerular feedback TGF is a feedback system inside the kidneys. The size of the TGF response is directly dependent upon these changes.

A Cellular And Molecular Approach. The agents are vasoactive substances that alter either the magnitude or the sensitivity of the TGF response.

Tubuloglomerular Feedback and Glomerulotubular Balance

The muscle balanfe in the afferent arteriole tubuloglomerluar modified based on the difference between the sensed concentration and a target concentration. A large sodium chloride concentration is indicative of an elevated GFR, while low sodium chloride concentration indicates a depressed Tubulgolomerular.

Solvent drag sodium chloride urea glucose oligopeptides protein. Compliance Vascular resistance Pulse Perfusion. Glomerulotubular balance can be thought of as an additional layer of protection if mechanisms of tubuloglomerular feedbackthat normalize rates of GFR, momentarily fail or are slow to be triggered.


Increased GFR increases the oncotic pressure of the blood exiting the glomerulus. The critical target of the trans-JGA signaling cascade is the glomerular afferent arteriole; its response consists of an increase in net vasoconstrictor tone resulting in reductions of glomerular capillary pressure PGC and glomerular plasma flow.

The increased load on the kidney of high-protein diet is a result of an increase in reabsorption of NaC.

Saunders, An Imprint of Elsevier. It involves the concept of purinergic signalingin which an increased distal tubular sodium chloride concentration causes a basolateral release of adenosine from the macula densa cells. ATP consumed in active transport by the macula densa also contributes to the formation of adenosine by 5- nucleotidase Thomson et al. Fluid balance Darrow Yannet diagram Body water: This page was last edited on 16 Decemberat Constricting the smooth muscle cells in the afferent arteriole, results in a reduced concentration of chloride at the MD.

Tubuloglomerular feedback is one of several mechanisms the kidney uses to regulate glomerular filtration rate GFR. Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction. Journal of the American Society of Nephrology.

Tubuloglomerular feedback results in the regulation of GFR. Glomerulotubular balance thus guarantees that any momentarily increased tubular flow is resorbed by proximal segments of the nephron which have significantly greater capacity for resorbing large fluid volumes.

Views Read Edit View history. Vander’s Renal Physiology 8th ed. Consequently, the regulation of GFR also results in the autoregulation of renal blood flow.

Glomerulotubular Balance | Pathway Medicine

Secretion clearance Pharmacokinetics Clearance of medications Urine flow rate. It seems likely that changes in GFR result in modification of the starling forces in the peritubular capillaries resulting in proportionally increased or decreased total nephronic resorption.

The kidney maintains the electrolyte concentrations, osmolality, and acid-base balance of blood plasma within the narrow limits that are compatible with effective cellular function; and the kidney participates in blood pressure regulation and in the maintenance of steady whole-organism water volume [4].

Blood flow Compliance Vascular resistance Pulse Perfusion. Angiotensin II constricts preferentially the efferent arterioles, as the efferent arterioles are much more sensitive to angiotensin II.


Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis.

Efferent arterioles appear to play a lesser role; experimental evidence supports tubuloglomeruoar vasoconstriction and vasodilation, with perhaps the former in the lower range and the latter in the higher range of NaCl concentrations 2. Annual Review of Physiology. The macula densa’s position enables it to rapidly alter afferent arteriolar resistance in response to changes in the flow rate through the distal nephron. A drop in arterial blood pressure causes both a decrease in GFR and a decrease in renal blood flow.

Distal tubule NaCl delivery is proportionate to glomerular filtration rate. The mechanistic basis of glomerulotubular balance is poorly understood but appears to act completely independently of neuroendocrine regulatory mechanisms and is likely an intrinsic property of the nephron itself.

Glomerulotubular balance ties peritubular capillary filtrate reabsorption to glomerular filtration rate. Efferent arteriolar constriction increases glomerular capillary pressure.

As the TAL ascends through the renal cortex, it encounters its own glomerulusbringing the macula densa to rest at the angle between the afferent and efferent arterioles. In glomerulotubular balance, filtration at the glomerulus alters the oncotic pressure of the plasma that exits the glomerulus and flows into the peritubular capillaries.

Excluding loop diuretic use, the usual situation that causes a reduction in reabsorption of NaCl via the NKCC2 at the macula densa is a low tubular lumen concentration of NaCl. The afferent arteriole cells release renin, leading to intrarenal angiotensin II formation.

Journal of Tubuloglomerulra Biology. The TGF mechanism is a negative feedback loop in which the chloride ion concentration is sensed downstream in the nephron by the macula densa MDcells in the tubular wall near the end of TAL and the glomerulus. Tubuloglomerular Feedback and Glomerulotubular Balance.